Structural insights into the activation mechanism of dynamin-like EHD ATPases.

Abstract

Eps15 (epidermal growth factor receptor pathway substrate 15)-homology domain containing proteins (EHDs) comprise a family of dynamin-related mechano-chemical ATPases involved in cellular membrane trafficking. Previous studies have revealed the structure of the EHD2 dimer, but the molecular mechanisms of membrane recruitment and assembly have remained… (More)
DOI: 10.1073/pnas.1614075114

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