Structural insights into the YAP and TEAD complex.

  title={Structural insights into the YAP and TEAD complex.},
  author={Ze Li and Bin Zhao and Ping Wang and Erwei Song and Zhenghong Dong and Huirong Yang and Kun Liang Guan and Yanhui Xu},
  journal={Genes & development},
  volume={24 3},
The Yes-associated protein (YAP) transcriptional coactivator is a key regulator of organ size and a candidate human oncogene inhibited by the Hippo tumor suppressor pathway. The TEAD family of transcription factors binds directly to and mediates YAP-induced gene expression. Here we report the three-dimensional structure of the YAP (residues 50-171)-TEAD1 (residues 194-411) complex, in which YAP wraps around the globular structure of TEAD1 and forms extensive interactions via three highly… CONTINUE READING
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Structural basis of YAP recognition by TEAD 4 in the Hippo pathway

  • SW Chan, XQ Zhang, M Walsh, CJ Lim, W Hong, H Song
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