Structural insights into the YAP and TEAD complex.

@article{Li2010StructuralII,
  title={Structural insights into the YAP and TEAD complex.},
  author={Ze Li and Bin Zhao and Ping Wang and Erwei Song and Zhenghong Dong and Huirong Yang and Kun Liang Guan and Yanhui Xu},
  journal={Genes & development},
  year={2010},
  volume={24 3},
  pages={235-40}
}
The Yes-associated protein (YAP) transcriptional coactivator is a key regulator of organ size and a candidate human oncogene inhibited by the Hippo tumor suppressor pathway. The TEAD family of transcription factors binds directly to and mediates YAP-induced gene expression. Here we report the three-dimensional structure of the YAP (residues 50-171)-TEAD1 (residues 194-411) complex, in which YAP wraps around the globular structure of TEAD1 and forms extensive interactions via three highly… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
67 Citations
37 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 67 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Structural basis of YAP recognition by TEAD 4 in the Hippo pathway

  • SW Chan, XQ Zhang, M Walsh, CJ Lim, W Hong, H Song
  • 2010

Similar Papers

Loading similar papers…