Structural insights into the SENP6 Loop1 structure in complex with SUMO2

@article{Alegre2014StructuralII,
  title={Structural insights into the SENP6 Loop1 structure in complex with SUMO2},
  author={K. O. Alegre and D. Reverter},
  journal={Protein Science},
  year={2014},
  volume={23}
}
  • K. O. Alegre, D. Reverter
  • Published 2014
  • Biology, Medicine
  • Protein Science
  • The SENP proteases regulate the SUMO conjugates in the cell by cleaving SUMO from target proteins. SENP6 and SENP7 are the most divergent members of the SENP/ULP protease family in humans by the presence of insertions in their catalytic domains. Loop1 insertion is determinant for the SUMO2/3 activity and specificity on SENP6 and SENP7. To gain structural insights into the role of Loop1, we have designed a chimeric SENP2 with the insertion of Loop1 into its sequence. The structure of SENP2‐Loop1… CONTINUE READING
    6 Citations

    References

    SHOWING 1-10 OF 41 REFERENCES
    A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.
    • 169
    The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.
    • 113
    • PDF
    Structure of the Human SENP7 Catalytic Domain and Poly-SUMO Deconjugation Activities for SENP6 and SENP7*
    • 106
    • PDF
    Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates
    • 122
    Swapping Small Ubiquitin-like Modifier (SUMO) Isoform Specificity of SUMO Proteases SENP6 and SENP7*
    • 20
    • PDF
    Characterization of SENP7, a SUMO-2/3-specific isopeptidase.
    • 88
    • PDF
    The SUMO-Specific Protease SENP5 Is Required for Cell Division
    • 162
    • PDF
    Characterization of the Localization and Proteolytic Activity of the SUMO-specific Protease, SENP1*
    • 171
    • PDF
    Distribution and paralogue specificity of mammalian deSUMOylating enzymes.
    • 83
    • PDF
    Small Ubiquitin-related Modifier (SUMO)-specific Proteases
    • 131
    • PDF