Structural insights into the SENP6 Loop1 structure in complex with SUMO2

  title={Structural insights into the SENP6 Loop1 structure in complex with SUMO2},
  author={K. O. Alegre and D. Reverter},
  journal={Protein Science},
  • K. O. Alegre, D. Reverter
  • Published 2014
  • Biology, Medicine
  • Protein Science
  • The SENP proteases regulate the SUMO conjugates in the cell by cleaving SUMO from target proteins. SENP6 and SENP7 are the most divergent members of the SENP/ULP protease family in humans by the presence of insertions in their catalytic domains. Loop1 insertion is determinant for the SUMO2/3 activity and specificity on SENP6 and SENP7. To gain structural insights into the role of Loop1, we have designed a chimeric SENP2 with the insertion of Loop1 into its sequence. The structure of SENP2‐Loop1… CONTINUE READING
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