Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase.

@article{FerrerOrta2009StructuralII,
  title={Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase.},
  author={Cristina Ferrer-Orta and Rebeca Garc{\'i}a Agudo and Esteban Domingo and N{\'u}ria Verdaguer},
  journal={Current opinion in structural biology},
  year={2009},
  volume={19 6},
  pages={
          752-8
        }
}
RNA-dependent RNA polymerases (RdRPs) play central roles in both transcription and viral genome replication. In picornaviruses, these functions are catalyzed by the virally encoded RdRP, termed 3D. Polymerase 3D also catalyzes the covalent linkage of UMP to a tyrosine on the small protein VPg. Uridylylated VPg then serves as a protein primer for the initiation of RNA synthesis. Seven different crystal structures of foot-and-mouth disease virus (FMDV) 3D catalytic complexes have enhanced our… CONTINUE READING
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