Structural insights into proteoglycan-shaped Hedgehog signaling

@article{Whalen2013StructuralII,
  title={Structural insights into proteoglycan-shaped Hedgehog signaling},
  author={D. Whalen and Tomas Malinauskas and R. Gilbert and C. Siebold},
  journal={Proceedings of the National Academy of Sciences},
  year={2013},
  volume={110},
  pages={16420 - 16425}
}
  • D. Whalen, Tomas Malinauskas, +1 author C. Siebold
  • Published 2013
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • Significance The Hedgehog (Hh) signaling pathway plays key roles during embryonic development and remains active in adults. Mutations in the genes encoding the Hh signaling pathway proteins lead to developmental disorders and cancer. The glycosaminoglycan (GAG) chains of proteoglycans at the cell surface shape Hh gradients and signal transduction. We determined the crystal structures of Hh proteins with two different GAG chains, heparin and chondroitin sulfate. The GAG-binding site we… CONTINUE READING
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