Structural insights into neuronal K+ channel-calmodulin complexes.

  title={Structural insights into neuronal K+ channel-calmodulin complexes.},
  author={Karen Mruk and Shiven M D Shandilya and Robert O. Blaustein and Celia A Schiffer and William R Kobertz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 34},
Calmodulin (CaM) is a ubiquitous intracellular calcium sensor that directly binds to and modulates a wide variety of ion channels. Despite the large repository of high-resolution structures of CaM bound to peptide fragments derived from ion channels, there is no structural information about CaM bound to a fully folded ion channel at the plasma membrane. To determine the location of CaM docked to a functioning KCNQ K(+) channel, we developed an intracellular tethered blocker approach to measure… CONTINUE READING