Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.

@article{Julien2012StructuralII,
  title={Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.},
  author={Jean-Philippe Julien and Peter S Lee and Ian A. Wilson},
  journal={Immunological reviews},
  year={2012},
  volume={250 1},
  pages={180-98}
}
Human immunodeficiency virus-1 (HIV-1) envelope protein (Env) and influenza hemagglutinin (HA) are the surface glycoproteins responsible for viral entry into host cells, the first step in the virus life cycle necessary to initiate infection. These glycoproteins exhibit a high degree of sequence variability and glycosylation, which are used as strategies to escape host immune responses. Nonetheless, antibodies with broadly neutralizing activity against these viruses have been isolated that have… CONTINUE READING

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