Structural insights into ion conduction by channelrhodopsin 2

@article{Volkov2017StructuralII,
  title={Structural insights into ion conduction by channelrhodopsin 2},
  author={Oleksandr Volkov and Kirill Kovalev and Vitaly Polovinkin and Valentin I Borshchevskiy and Christian Bamann and Roman Astashkin and Egor Marin and Alexander Popov and Taras Balandin and Dieter Willbold and Georg Bueldt and Ernst Bamberg and Valentin Gordeliy},
  journal={Science},
  year={2017},
  volume={358}
}
The light-gated ion channel channelrhodopsin 2 (ChR2) from Chlamydomonas reinhardtii is a major optogenetic tool. Photon absorption starts a well-characterized photocycle, but the structural basis for the regulation of channel opening remains unclear. We present high-resolution structures of ChR2 and the C128T mutant, which has a markedly increased open-state lifetime. The structure reveals two cavities on the intracellular side and two cavities on the extracellular side. They are connected by… CONTINUE READING

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