Structural insights into human Kif7, a kinesin involved in Hedgehog signalling

  title={Structural insights into human Kif7, a kinesin involved in Hedgehog signalling},
  author={Marta Klejnot and Frank Kozielski},
  booktitle={Acta crystallographica. Section D, Biological crystallography},
Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic development. Kif7 and Kif27, a closely related kinesin in the same subfamily, are orthologues of the Drosophila melanogaster kinesin-like protein Costal-2 (Cos2). In vertebrates, they work together to… CONTINUE READING
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