Structural insights into calmodulin-regulated L-selectin ectodomain shedding.

  title={Structural insights into calmodulin-regulated L-selectin ectodomain shedding.},
  author={Jessica L. Gifford and Hiroaki Ishida and Hans J. Vogel},
  journal={The Journal of biological chemistry},
  volume={287 32},
The L-selectin glycoprotein receptor mediates the initial steps of leukocyte migration into secondary lymphoid organs and sites of inflammation. Following cell activation through the engagement of G-protein-coupled receptors or immunoreceptors, the extracellular domains of L-selectin are rapidly shed, a process negatively controlled via the binding of the ubiquitous eukaryotic calcium-binding protein calmodulin to the cytoplasmic tail of L-selectin. Here we present the solution structure of… CONTINUE READING


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Prediction of sterically induced alignment in a dilute liquid crystalline phase. Aid to protein structure determination by NMR

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