Structural insights into adrenergic receptor function and pharmacology.

  title={Structural insights into adrenergic receptor function and pharmacology.},
  author={Brian K. Kobilka},
  journal={Trends in pharmacological sciences},
  volume={32 4},
It has been over 50years since Sir James Black developed the first beta adrenergic receptor (βAR) blocker to treat heart disease. At that time, the concept of cell surface receptors was relatively new and not widely accepted, and most of the tools currently used to characterize plasma membrane receptors had not been developed. There has been remarkable progress in receptor biology since then, including the development of radioligand binding assays, the biochemical characterization of receptors… CONTINUE READING