Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development.

@article{Archbold2011StructuralII,
  title={Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development.},
  author={Julia K. Archbold and Jack Urquhart Flanagan and Harriet Watkins and Joseph J Gingell and Debbie L Hay},
  journal={Trends in pharmacological sciences},
  year={2011},
  volume={32 10},
  pages={591-600}
}
Secretin family G protein-coupled receptors (GPCRs) are important therapeutic targets for migraine, diabetes, bone disorders, inflammatory disorders and cardiovascular disease. They possess a large N-terminal extracellular domain (ECD) known to be the primary ligand-binding determinant. Structural determination of several secretin family GPCR ECDs in complex with peptide ligands has been achieved recently, providing insight into the molecular determinants of hormone binding. Some secretin… CONTINUE READING