Structural insights into Parkin substrate lysine targeting from minimal Miro substrates

@inproceedings{Klosowiak2016StructuralII,
  title={Structural insights into Parkin substrate lysine targeting from minimal Miro substrates},
  author={Julian L. Klosowiak and Sungjin Park and Kyle P. Smith and Michael E. French and Pamela J. Focia and Douglas M. Freymann and Sarah E. Rice},
  booktitle={Scientific reports},
  year={2016}
}
Hereditary Parkinson's disease is commonly caused by mutations in the protein kinase PINK1 or the E3 ubiquitin ligase Parkin, which function together to eliminate damaged mitochondria. PINK1 phosphorylates both Parkin and ubiquitin to stimulate ubiquitination of dozens of proteins on the surface of the outer mitochondrial membrane. However, the mechanisms… CONTINUE READING