Structural insights into Atg10-mediated formation of the autophagy-essential Atg12-Atg5 conjugate.

@article{Yamaguchi2012StructuralII,
  title={Structural insights into Atg10-mediated formation of the autophagy-essential Atg12-Atg5 conjugate.},
  author={Masaya Yamaguchi and Nobuo N Noda and Hayashi Yamamoto and Takayuki Shima and Hiroyuki Kumeta and Yoshihiro Kobashigawa and Rinji Akada and Yoshinori Ohsumi and Fuyuhiko Inagaki},
  journal={Structure},
  year={2012},
  volume={20 7},
  pages={1244-54}
}
The Atg12-Atg5 conjugate, which is formed by an ubiquitin-like conjugation system, is essential to autophagosome formation, a central event in autophagy. Despite its importance, the molecular mechanism of the Atg12-Atg5 conjugate formation has not been elucidated. Here, we report the solution and crystal structures of Atg10 and Atg5 homologs from Kluyveromyces marxianus (Km), a thermotolerant yeast. KmAtg10 comprises an E2-core fold with characteristic accessories, including two β strands… CONTINUE READING

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