Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases


Type II topoisomerases alter DNA topology by forming a covalent DNA-cleavage complex that allows DNA transport through a double-stranded DNA break. We present the structures of cleavage complexes formed by the Streptococcus pneumoniae ParC breakage-reunion and ParE TOPRIM domains of topoisomerase IV stabilized by moxifloxacin and clinafloxacin, two… (More)
DOI: 10.1038/nsmb.1604


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