Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR.

@article{Chen2010StructuralII,
  title={Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR.},
  author={Hao Chen and Chengqi Yi and Jin Zhang and Wenru Zhang and Zhiyun Ge and Cai-Guang Yang and Chuan He},
  journal={EMBO reports},
  year={2010},
  volume={11 9},
  pages={685-90}
}
MexR functions as the primary regulator of the mexAB-oprM multidrug efflux expression in Pseudomonas aeruginosa. It has been shown that MexR senses oxidative stress by interprotomer disulphide bond formation between redox-active cysteines. This oxidation induces MexR to dissociate from the promoter DNA, thus activating the transcriptional expression of efflux pump genes. In this study, we present the crystal structure of MexR in its oxidized form at a resolution of 2.1 A. This crystal structure… CONTINUE READING
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