Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.

@article{Zhang2013StructuralII,
  title={Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.},
  author={Yan Zhang and Lin Fu and Xiaolong Qi and Zhenyi Zhang and Yuanxin Xia and Jianhang Jia and Jin Jiang and Yun M. Zhao and Geng Wu},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={2608}
}
Hedgehog (Hh) signalling regulates embryonic development and adult tissue homoeostasis. Mutations of its pathway components including Suppressor of Fused (Sufu) and Gli/Ci predispose to cancers and congenital anomalies. The Sufu-Gli protein complex occupies a central position in the vertebrate Hh signalling pathway, especially in mammals. Here structures of full-length human and Drosophila Sufu, the human Sufu-Gli complex, along with normal mode analysis and FRET measurement results, reveal… CONTINUE READING
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