Structural insight into the interaction of ADP-ribose with the PARP WWE domains.

@article{He2012StructuralII,
  title={Structural insight into the interaction of ADP-ribose with the PARP WWE domains.},
  author={Fahu He and Kengo Tsuda and Mari Takahashi and Kanako Kuwasako and Takaho Terada and Mikako Shirouzu and Satoru Watanabe and Takanori Kigawa and Naohiro Kobayashi and Peter G{\"u}ntert and Shigeyuki Yokoyama and Yutaka Muto},
  journal={FEBS letters},
  year={2012},
  volume={586 21},
  pages={3858-64}
}
The WWE domain is often identified in proteins associated with ubiquitination or poly-ADP-ribosylation. Structural information about WWE domains has been obtained for the ubiquitination-related proteins, such as Deltex and RNF146, but not yet for the poly-ADP-ribose polymerases (PARPs). Here we determined the solution structures of the WWE domains from PARP11 and PARP14, and compared them with that of the RNF146 WWE domain. NMR perturbation experiments revealed the specific differences in their… CONTINUE READING

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