Structural insight into the heme-based redox sensing by DosS from Mycobacterium tuberculosis.

@article{Cho2009StructuralII,
  title={Structural insight into the heme-based redox sensing by DosS from Mycobacterium tuberculosis.},
  author={Ha Yeon Cho and Hyo Je Cho and Young Min Kim and Jeong Il Oh and Beom Sik Kang},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 19},
  pages={13057-67}
}
Mycobacterium tuberculosis is thought to undergo transformation into its non-replicating persistence state under the influence of hypoxia or nitric oxide (NO). This transformation is thought to be mediated via two sensor histidine kinases, DosS and DosT, each of which contains two GAF domains that are responsible for detecting oxygen tension. In this study we determined the crystal structures of the first GAF domain (GAF-A) of DosS, which shows an interaction with a heme. A b-type heme was… CONTINUE READING