Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.

@article{Hlouchov2009StructuralII,
  title={Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.},
  author={Kl{\'a}ra Hlouchov{\'a} and Cyril Barinka and Jan Konvalinka and Jacek T Lubkowski},
  journal={The FEBS journal},
  year={2009},
  volume={276 16},
  pages={4448-62}
}
Glutamate carboxypeptidase III (GCPIII) is a metalloenzyme that belongs to the transferrin receptor/glutamate carboxypeptidase II (GCPII; EC 3.4.17.21) superfamily. GCPIII has been studied mainly because of its evolutionary relationship to GCPII, an enzyme involved in a variety of neuropathologies and malignancies, such as glutamatergic neurotoxicity and… CONTINUE READING