Structural insight into the constitutive repression function of the nuclear receptor Rev-erbbeta.

@article{Woo2007StructuralII,
  title={Structural insight into the constitutive repression function of the nuclear receptor Rev-erbbeta.},
  author={Eui-Jeon Woo and Dae Gwin Jeong and Mi-Youn Lim and Seung Jun Kim and Kyung-Jin Kim and Sei-Mee Yoon and Byoung-Chul Park and Seong Eon Ryu},
  journal={Journal of molecular biology},
  year={2007},
  volume={373 3},
  pages={735-44}
}
The Rev-erb family is an orphan nuclear receptor acting as a negative regulator of transcription. Rev-erbalpha and Rev-erbbeta are crucial components of the circadian clock and involved in various lipid homeostasis. They are unique nuclear receptors that lack the activation function 2 helix (AF2-helix) required for ligand-dependent activation by other members of nuclear receptors. Here, we report the crystal structure of Rev-erbbeta (NR1D2) in a dimeric arrangement. The putative ligand-binding… CONTINUE READING

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