Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function.

@article{Shang2012StructuralII,
  title={Structural insight into how Pseudomonas aeruginosa peptidoglycanhydrolase Tse1 and its immunity protein Tsi1 function.},
  author={Guijun Shang and XiuHua Liu and Defen Lu and Junbing Zhang and Ning Li and Chunyuan Zhu and Shiheng Liu and Qian Yu and Yanyu Zhao and Heqiao Zhang and Junqiang Hu and Huaixing Cang and Sujuan Xu and Lichuan Gu},
  journal={The Biochemical journal},
  year={2012},
  volume={448 2},
  pages={201-11}
}
Tse1 (Tse is type VI secretion exported), an effector protein produced by Pseudomonas aeruginosa, is an amidase that hydrolyses the γ-D-glutamyl-DAP (γ-D-glutamyl-L-meso-diaminopimelic acid) linkage of the peptide bridge of peptidoglycan. P. aeruginosa injects Tse1 into the periplasm of recipient cells, degrading their peptidoglycan, thereby helping itself to compete with other bacteria. Meanwhile, to protect itself from injury by Tse1, P. aeruginosa expresses the cognate immunity protein Tsi1… CONTINUE READING