Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family

  title={Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family},
  author={Paul Thaw and Svetlana E. Sedelnikova and Tatyana A. Muranova and Sebastian Wiese and Sylvia Ayora and J. Alonso and Arie B Brinkman and Jasper Akerboom and John van der Oost and John B Rafferty},
  journal={Nucleic Acids Research},
  pages={1944 - 1944}
The Lrp/AsnC family of transcriptional regulatory proteins is found in both archaea and bacteria. Members of the family influence cellular metabolism in both a global (Lrp) and specific (AsnC) manner, often in response to exogenous amino acid effectors. In the present study we have determined both the first bacterial and the highest resolution structures for members of the family. Escherichia coli AsnC is a specific gene regulator whose activity is triggered by asparagine binding. Bacillus… 

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