Structural insight into gene duplication, gene fusion and domain swapping in the evolution of PLP-independent amino acid racemases.

Abstract

The X-ray crystal structure has revealed two similar alpha/beta domains of aspartate racemase (AspR) from Pyrococcus horikoshii OT3, and identified a pseudo mirror-symmetric distribution of the residues around its active site [Liu et al. (2002) J. Mol. Biol. 319, 479-489]. Structural homology and functional similarity between the two domains suggested that… (More)

Topics

  • Presentations referencing similar topics