Structural insight into autoinhibition and histone H3-induced activation of DNMT3A

  title={Structural insight into autoinhibition and histone H3-induced activation of DNMT3A},
  author={Xue Feng Guo and Ling Wang and Jie Li and Zhanyu Ding and Jianxiong Xiao and Xiaotong Yin and Shuang He and Pan Shi and Liping Dong and Guohong Li and Changlin Tian and Jiawei Wang and Y. H. Cong and Yanhui Xu},
DNA methylation is an important epigenetic modification that is essential for various developmental processes through regulating gene expression, genomic imprinting, and epigenetic inheritance. Mammalian genomic DNA methylation is established during embryogenesis by de novo DNA methyltransferases, DNMT3A and DNMT3B, and the methylation patterns vary with developmental stages and cell types. DNA methyltransferase 3-like protein (DNMT3L) is a catalytically inactive paralogue of DNMT3 enzymes… CONTINUE READING
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