Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase

@article{Burkhard2001StructuralII,
  title={Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase},
  author={P. Burkhard and P. Dominici and C. Borri-Voltattorni and J. Jansonius and V. Malashkevich},
  journal={Nature Structural Biology},
  year={2001},
  volume={8},
  pages={963-967}
}
DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of l-3,4-dihydroxyphenylalanine (l-DOPA) and l-5-hydroxytryptophan, respectively. DDC has been implicated in a number of clinic disorders, including Parkinson's disease and hypertension. Peripheral inhibitors of DDC are currently used to treat these diseases. We present the crystal structures of ligand-free DDC and its complex with the anti-Parkinson drug carbiDOPA… Expand
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