Structural identification of the degradation products of the antitumor peptide antagonist [Arg6,D-Trp7,9,MePhe8]substance P (6-11).

@article{Reubsaet1995StructuralIO,
  title={Structural identification of the degradation products of the antitumor peptide antagonist [Arg6,D-Trp7,9,MePhe8]substance P (6-11).},
  author={Jan Leon Egge Reubsaet and Jos H. Beijnen and Auke Bult and E. Hop and R Vermaas and Y Kellekule and J Jantina Kettenes-van den Bosch and Willy J. M. Underberg},
  journal={Analytical chemistry},
  year={1995},
  volume={67 23},
  pages={4431-6}
}
The basic hexapeptide antagonist [Arg6,D-Trp7,9,MePhe8]-substance P (6-11) was degraded in acid and alkaline media. In acid solution, only one degradation product is found whereas in alkaline solution at least six products are formed. These compounds were analytically characterized and structurally identified by reversed-phase high-performance liquid chromatography, capillary electrophoresis, liquid chromatography/mass spectrometry, fast atom bombardment tandem mass spectrometry, optical… CONTINUE READING
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