Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

@article{Wiley1981StructuralIO,
  title={Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation},
  author={Don C. Wiley and Ian A. Wilson and John J. Skehel},
  journal={Nature},
  year={1981},
  volume={289},
  pages={373-378}
}
Four ‘antigenic sites’ on the three-dimensional structure of the influenza haemagglutinin are identified. At least one amino acid substitution in each site seems to be required for the production of new epidemic strains between 1968 and 1975. 
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