Structural identification by mass spectrometry of a novel antimicrobial peptide from the venom of the solitary bee Osmia rufa (Hymenoptera: Megachilidae).

@article{Stcklin2010StructuralIB,
  title={Structural identification by mass spectrometry of a novel antimicrobial peptide from the venom of the solitary bee Osmia rufa (Hymenoptera: Megachilidae).},
  author={Reto St{\"o}cklin and Philippe S. Favreau and Robert Thai and Jochen Pflugfelder and Philippe Bulet and Dietrich Mebs},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2010},
  volume={55 1},
  pages={20-7}
}
The venom from the solitary bee Osmia rufa (Hymenoptera: Megachilidae) was analyzed using mass spectrometry (MS)-based techniques. Sensitive proteomic methods such as on-line LC-ESI-MS and nanoESI-MS analyses revealed more than 50 different compounds with molecular masses ranging from 400 to 4000Da. The major component has a monoisotopic molecular mass of 1924.20Da and its amino acid sequence was elucidated by de novo sequencing using tandem mass spectrometry and Edman degradation. This 17… CONTINUE READING
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