Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex.

@article{Seok2017StructuralHC,
  title={Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex.},
  author={Seung-Hyeon Seok and Woojong Lee and Li Jiang and Kaivalya Molugu and Aiping Zheng and Yitong Li and Sanghyun Park and Christopher A. Bradfield and Yongna Xing},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 21},
  pages={
          5431-5436
        }
}
The aryl hydrocarbon receptor (AHR) belongs to the PAS (PER-ARNT-SIM) family transcription factors and mediates broad responses to numerous environmental pollutants and cellular metabolites, modulating diverse biological processes from adaptive metabolism, acute toxicity, to normal physiology of vascular and immune systems. The AHR forms a transcriptionally active heterodimer with ARNT (AHR nuclear translocator), which recognizes the dioxin response element (DRE) in the promoter of downstream… CONTINUE READING
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