Structural glycobiology of heparinase II from Pedobacter heparinus

  title={Structural glycobiology of heparinase II from Pedobacter heparinus},
  author={C. L. Fernandes and Gabriela B. Escouto and H. Verli},
  journal={Journal of Biomolecular Structure and Dynamics},
  pages={1092 - 1102}
The current work presents a conformational evaluation of heparinase II (hepII) from Pedobacter heparinus, employing molecular dynamics (MD) simulations, in order to characterize the main features of the enzyme dynamics, as well as the role of the glycan and metal components on the protein scaffold. Accordingly, four systems were simulated, encompassing nonglycosylated hepII without structural ions, nonglycosylated hepII with Zn2+, nonglycosylated hepII with Ca2+, and glycosylated hepII with Zn2… Expand
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