Structural genomics of GPCRs.

  title={Structural genomics of GPCRs.},
  author={Kenneth Lundstrom},
  journal={Trends in biotechnology},
  volume={23 2},
G protein-coupled receptors (GPCRs) are targets for 60-70% of drugs in development today. Traditionally, the drug discovery process has relied on screening of chemical compounds to identify novel and more-efficient drug molecules. Structure-based drug design, however, provides a targeted approach but has been severely hampered by limited knowledge of high-resolution structures of GPCRs owing to the difficulties encountered in their expression, purification and crystallization. In addition to… CONTINUE READING

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