Structural genomics for membrane proteins

  title={Structural genomics for membrane proteins},
  author={Kenneth Lundstrom},
  journal={Cellular and Molecular Life Sciences CMLS},
  • K. Lundstrom
  • Published 23 February 2006
  • Biology, Chemistry
  • Cellular and Molecular Life Sciences CMLS
Abstract.Structure-based drug discovery has proven useful in improving and shortening the drug development process. The approach of structural genomics to study a large number of targets in parallel has been commonly applied to protein families and even whole genomes. Paradoxically, although membrane proteins represent the largest type of drug targets, up to 70% today, determination of their structure has been modest compared to that of soluble proteins. Because membrane proteins are important… 

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