Structural genomics for membrane proteins

@article{Lundstrom2006StructuralGF,
  title={Structural genomics for membrane proteins},
  author={K. Lundstrom},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2006},
  volume={63},
  pages={2597-2607}
}
  • K. Lundstrom
  • Published 2006
  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
Abstract.Structure-based drug discovery has proven useful in improving and shortening the drug development process. The approach of structural genomics to study a large number of targets in parallel has been commonly applied to protein families and even whole genomes. Paradoxically, although membrane proteins represent the largest type of drug targets, up to 70% today, determination of their structure has been modest compared to that of soluble proteins. Because membrane proteins are important… Expand
98 Citations
Structure-function relationships in membrane protein families
  • PDF
Rational and Irrational Approaches to Convince a Protein to Crystallize
  • 1
  • PDF
Membrane Protein Structure: Techniques
  • 1
Heterologous expression of membrane proteins for structural analysis.
  • 22
Detection of Ligand Binding to Nucleotide Sugar Transporters by STD NMR Spectroscopy
  • 9
Recent developments in membrane-protein structural genomics
  • 14
  • PDF
Solution NMR study of integral membrane proteins.
  • 65
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 113 REFERENCES
Structural genomics on membrane proteins: mini review.
  • K. Lundstrom
  • Chemistry, Medicine
  • Combinatorial chemistry & high throughput screening
  • 2004
  • 51
Structural genomics on membrane proteins: the MePNet approach.
  • K. Lundstrom
  • Medicine, Biology
  • Current opinion in drug discovery & development
  • 2004
  • 22
Applications of NMR to structure-based drug design in structural genomics
  • R. Powers
  • Biology, Medicine
  • Journal of Structural and Functional Genomics
  • 2004
  • 18
  • PDF
Protein expression systems for structural genomics and proteomics.
  • S. Yokoyama
  • Biology, Medicine
  • Current opinion in chemical biology
  • 2003
  • 251
Structural genomics on membrane proteins: comparison of more than 100 GPCRs in 3 expression systems
  • 125
The future of G protein-coupled receptors as targets in drug discovery.
  • K. Lundstrom
  • Medicine, Chemistry
  • IDrugs : the investigational drugs journal
  • 2005
  • 24
Crystallisation of membrane proteins mediated by antibody fragments.
  • 184
  • PDF
...
1
2
3
4
5
...