Structural-functional study of glycine-and-proline-containing peptides (Glyprolines) as potential neuroprotectors

Abstract

A synthetic scheme for preparation of (Gly-Pro) n , (Pro-Gly) n (n = 2, 3), and (Pro-Gly-Pro) n (n = 1, 2) peptides was elaborated. The effect of the synthesized peptides and the Gly-Pro and Pro-Gly dipeptides on survival of cultured cells of PC12 rat pheochromocytoma was studied under the conditions of oxidative stress induced by brief incubation of the… (More)
DOI: 10.1134/S1068162009020022

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