Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity.


The structure-guided design of chloride-conducting channelrhodopsins has illuminated mechanisms underlying ion selectivity of this remarkable family of light-activated ion channels. The first generation of chloride-conducting channelrhodopsins, guided in part by development of a structure-informed electrostatic model for pore selectivity, included both the… (More)
DOI: 10.1073/pnas.1523341113


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