Structural flexibility in the Burkholderia mallei genome.


The complete genome sequence of Burkholderia mallei ATCC 23344 provides insight into this highly infectious bacterium's pathogenicity and evolutionary history. B. mallei, the etiologic agent of glanders, has come under renewed scientific investigation as a result of recent concerns about its past and potential future use as a biological weapon. Genome analysis identified a number of putative virulence factors whose function was supported by comparative genome hybridization and expression profiling of the bacterium in hamster liver in vivo. The genome contains numerous insertion sequence elements that have mediated extensive deletions and rearrangements of the genome relative to Burkholderia pseudomallei. The genome also contains a vast number (>12,000) of simple sequence repeats. Variation in simple sequence repeats in key genes can provide a mechanism for generating antigenic variation that may account for the mammalian host's inability to mount a durable adaptive immune response to a B. mallei infection.

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@article{Nierman2004StructuralFI, title={Structural flexibility in the Burkholderia mallei genome.}, author={William C. Nierman and David DeShazer and Heenam Stanley Kim and Herv{\'e} Tettelin and Karen E. Nelson and Tamara V. Feldblyum and Ricky L. Ulrich and Catherine M. Ronning and Lauren M. Brinkac and Sean C. Daugherty and Tanja D Davidsen and Robert T Deboy and George Dimitrov and Robert J. Dodson and A. Scott Durkin and Michelle L Gwinn and Daniel H. Haft and Hoda M. Khouri and James F. Kolonay and Ramana Madupu and Yasmin Mohammoud and William C. Nelson and Diana Radune and Claudia M Romero and Saul H Sarria and Jeremy D. Selengut and Christine E. Shamblin and Steven Sullivan and Owen White and Yan Yu and Nikhat Zafar and Liwei Zhou and Claire M. Fraser}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2004}, volume={101 39}, pages={14246-51} }