Structural findings in the basal ganglia in genetically determined and idiopathic Parkinson's disease.

@article{Reetz2009StructuralFI,
  title={Structural findings in the basal ganglia in genetically determined and idiopathic Parkinson's disease.},
  author={Kathrin Reetz and Christian Gaser and Christine Klein and Johannes M. Hagenah and Christian B{\"u}chel and S. Gottschalk and Peter P. Pramstaller and Hartwig R. Siebner and F. Binkofski},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2009},
  volume={24 1},
  pages={
          99-103
        }
}
A bilateral compensatory increase of basal ganglia (BG) gray matter value (GMV) was recently demonstrated in asymptomatic Parkin mutation carriers, who likely have an increased risk to develop Parkinson's disease (PD). We hypothesized BG morphological changes in symptomatic Parkin mutation carriers (sPARKIN-MC) and idiopathic PD patients (iPD) after the occurrence of PD symptoms, reflecting the breakdown of compensatory mechanisms. Nine sPARKIN-MC, 14 iPD, and 24 controls were studied… CONTINUE READING

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