Structural features that give rise to the unusual stability of RNA hairpins containing GNRA loops.

@article{Heus1991StructuralFT,
  title={Structural features that give rise to the unusual stability of RNA hairpins containing GNRA loops.},
  author={Hans A. Heus and Arthur Pardi},
  journal={Science},
  year={1991},
  volume={253 5016},
  pages={
          191-4
        }
}
The most frequently occurring RNA hairpins in 16S and 23S ribosomal RNA contain a tetranucleotide loop that has a GNRA consensus sequence. The solution structures of the GCAA and GAAA hairpins have been determined by nuclear magnetic resonance spectroscopy. Both loops contain an unusual G-A base pair between the first and last residue in the loop, a hydrogen bond between a G base and a phosphate, extensive base stacking, and a hydrogen bond between a sugar 2'-end OH and a base. These… CONTINUE READING

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