Structural features of various proglumide-related cholecystokinin receptor antagonists.

@article{Jensen1986StructuralFO,
  title={Structural features of various proglumide-related cholecystokinin receptor antagonists.},
  author={Robert Thomas Jensen and Z C Zhou and Robert B. Murphy and Steven W. Jones and Ivo Setnikar and Lucio Rovati and Jerry Gardner},
  journal={The American journal of physiology},
  year={1986},
  volume={251 6 Pt 1},
  pages={G839-46}
}
Thirteen proglumide derivatives that varied in the length of the di-n-alkyl group and in the substitutions on the benzoyl moiety were tested for their ability to interact with guinea pig pancreatic cholecystokinin (CCK) receptors. Each derivative was more potent than proglumide. There was a close correlation between their abilities to inhibit CCK-stimulated amylase release and to inhibit binding of 125I-CCK. For the di-n-alkyl derivatives the relative potency was n-pentyl greater than n-hexyl… CONTINUE READING