Structural features of human DJ-1 in distinct Cys106 oxidative states and their relevance to its loss of function in disease.

Abstract

DJ-1 (PARK7) is a multifunctional protein linked to the onset and progression of a number of diseases, most of which are associated with high oxidative stress. The Cys106 of DJ-1 is unusually reactive and thus sensitive to oxidation, and due to high oxidative stress it was observed to be in various oxidized states in disease condition. The oxidation state… (More)
DOI: 10.1016/j.bbagen.2017.08.017

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