Structural features of allergenic molecules.

  title={Structural features of allergenic molecules.},
  author={Rob C Aalberse},
  journal={Chemical immunology and allergy},
In this paper the relation between protein allergenicity (the capacity to induce IgE antibody production or the capacity to activate mast cells sensitized with IgE antibodies induced by a cross-reactive allergen) and protein structure is discussed. While cross-reactivity is to a large degree predictable from primary sequence comparisons, the IgE-inducing capacity is mostly determined by factors other than the primary sequence. Two routes to IgE are discussed: (1) the atopic route (used by… CONTINUE READING

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