Structural features of MHC class I molecules that might facilitate alternative pathways of presentation.

@article{Hansen2000StructuralFO,
  title={Structural features of MHC class I molecules that might facilitate alternative pathways of presentation.},
  author={Ted H. Hansen and Ganesaratnam K. Balendiran and Joyce C. Solheim and David Ostrov and Stanley G. Nathenson},
  journal={Immunology today},
  year={2000},
  volume={21 2},
  pages={83-8}
}
Comparisons of the structures of different mouse MHC class I molecules define how polymorphic residues determine the unique structural motif and atomic anchoring of their bound peptides. Here, Ted Hansen and colleagues speculate that quantitative differences in how class I molecules interact with peptide, beta2-microglobulin and molecular chaperones that facilitate peptide loading might determine their relative participation in different pathways of antigen presentation.