Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription.

@article{Berkhout2001StructuralFI,
  title={Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription.},
  author={Ben Berkhout and Nadine L Vastenhouw and B I Klasens and Hendrik Huthoff},
  journal={RNA},
  year={2001},
  volume={7 8},
  pages={1097-114}
}
Two obligatory DNA strand transfers take place during reverse transcription of a retroviral RNA genome. The first strand transfer is facilitated by terminal repeat (R) elements in the viral genome. This strand-transfer reaction depends on base pairing between the cDNA of the 5'R and the 3'R. There is accumulating evidence that retroviral R regions contain features other than sequence complementarity that stimulate this critical nucleic acid hybridization step. The R region of the human… CONTINUE READING