Structural features and biochemical properties of TNF-<ce:italic>α</ce:italic> converting enzyme (TACE)

@article{Moss1997StructuralFA,
  title={Structural features and biochemical properties of TNF-<ce:italic>α</ce:italic> converting enzyme (TACE)},
  author={Melvin L. Moss and S C Jin and J. David Becherer and David M Bickett and Dwight Willard},
  journal={Journal of Neuroimmunology},
  year={1997},
  volume={72},
  pages={127-129}
}
Tumor necrosis factor-a is a potent cytokine, secreted primarily by activated monocytes and macrophages, that possesses a broad range of immunomodulating properties. Involvement of this cytokine has been validated in disease states such as arthritis and Crohn’s disease and implicated in diverse neuroimmunological pathologies such as multiple sclerosis, Alzheimers and stroke. TNF-a is initially synthesized as a 26 kDa precursor molecule that is subsequently processed to the mature form by… CONTINUE READING