Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis.


Even though high-fidelity polymerases copy DNA with remarkable accuracy, some base-pair mismatches are incorporated at low frequency, leading to spontaneous mutagenesis. Using high-resolution X-ray crystallographic analysis of a DNA polymerase that catalyzes replication in crystals, we observe that a C • A mismatch can mimic the shape of cognate base pairs… (More)
DOI: 10.1073/pnas.1114496108

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