Structural evidence for solvent-stabilisation by aspartic acid as a mechanism for halophilic protein stability in high salt concentrations.

@article{Lenton2016StructuralEF,
  title={Structural evidence for solvent-stabilisation by aspartic acid as a mechanism for halophilic protein stability in high salt concentrations.},
  author={Samuel Lenton and Danielle L Walsh and Natasha H Rhys and Alan K Soper and Lorna Dougan},
  journal={Physical chemistry chemical physics : PCCP},
  year={2016},
  volume={18 27},
  pages={18054-62}
}
Halophilic organisms have adapted to survive in high salt environments, where mesophilic organisms would perish. One of the biggest challenges faced by halophilic proteins is the ability to maintain both the structure and function at molar concentrations of salt. A distinct adaptation of halophilic proteins, compared to mesophilic homologues, is the abundance of aspartic acid on the protein surface. Mutagenesis and crystallographic studies of halophilic proteins suggest an important role for… CONTINUE READING