Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma.

@article{Matsushima2007StructuralEF,
  title={Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma.},
  author={Ayami Matsushima and Yoshimitsu Kakuta and Takamasa Teramoto and Takumi Koshiba and Xiaohui Liu and Hiroyuki Okada and Takatoshi Tokunaga and Shun-ichiro Kawabata and Makoto Kimura and Yasuyuki Shimohigashi},
  journal={Journal of biochemistry},
  year={2007},
  volume={142 4},
  pages={517-24}
}
Many lines of evidence reveal that bisphenol A (BPA) functions at very low doses as an endocrine disruptor. The human estrogen-related receptor gamma (ERR gamma) behaves as a constitutive activator of transcription, although the endogenous ligand is unknown. We have recently demonstrated that BPA binds strongly to ERR gamma (K(D) = 5.5 nM), but not to the estrogen receptor (ER). BPA preserves the ERR gamma's basal constitutive activity, and protects the selective ER modulator 4-hydroxytamoxifen… CONTINUE READING