Structural evidence for direct hydride transfer from NADH to cytochrome P450nor.

  title={Structural evidence for direct hydride transfer from NADH to cytochrome P450nor.},
  author={Rieko Oshima and Shinya Fushinobu and Fei Su and Li Zhang and Naoki Takaya and Hirofumi Shoun},
  journal={Journal of molecular biology},
  volume={342 1},
Nitric oxide reductase cytochrome P450nor catalyzes an unusual reaction, direct electron transfer from NAD(P)H to bound heme. Here, we succeeded in determining the crystal structure of P450nor in a complex with an NADH analogue, nicotinic acid adenine dinucleotide, which provides conclusive evidence for the mechanism of the unprecedented electron transfer. Comparison of the structure with those of dinucleotide-free forms revealed a global conformational change accompanied by intriguing local… CONTINUE READING
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