Structural evidence for common functions and ancestry of the reovirus and adenovirus attachment proteins.

@article{Stehle2003StructuralEF,
  title={Structural evidence for common functions and ancestry of the reovirus and adenovirus attachment proteins.},
  author={Thilo Stehle and Terence S Dermody},
  journal={Reviews in medical virology},
  year={2003},
  volume={13 2},
  pages={
          123-32
        }
}
The crystal structure of the reovirus attachment protein, sigma1, reveals a fibre-like structure that is remarkably similar to that of the adenovirus attachment protein, fibre. Both proteins are trimers with head-and-tail morphology. They share unique domain structures and functional properties including defined regions of flexibility within the tail and an unusual symmetry mismatch with the pentameric viral capsid protein into which they are inserted. Moreover, the receptors for reoviruses and… CONTINUE READING
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