Structural evidence for a germline-encoded T cell receptor–major histocompatibility complex interaction 'codon'

@article{Feng2007StructuralEF,
  title={Structural evidence for a germline-encoded T cell receptor–major histocompatibility complex interaction 'codon'},
  author={Dan Feng and Christopher J Bond and Lauren K. Ely and Jennifer Maynard and K Christopher Garcia},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={975-983}
}
All complexes of T cell receptors (TCRs) bound to peptide–major histocompatibility complex (pMHC) molecules assume a stereotyped binding 'polarity', despite wide variations in TCR-pMHC docking angles. However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs. Here we determined the crystal structures of two TCRs encoded by the variable β-chain 8.2 (Vβ8.2), each bound to the MHC class II molecule I-Au, and did energetic mapping of Vα and V… CONTINUE READING
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